Cell populations were isolated from healthy adult human bone marrow precursors and peripheral blood (n=13). Chromatin immunoprecipitation, followed by deep sequencing (ChIP-seq) against endogenously tagged TopoIIα, and transposase-accessible chromatin with sequencing (ATAC-seq) was performed 4 hours after anthracycline exposure.ĭescription: ATAC-Seq from 8 sorted immune cell populations representing the early lymphoid hematopoietic differentiation cascade along the B cell lineage. The anthracycline-specific redistribution of TopoII and its association with histone eviction were addressed in K562 cells. Fragments identified using Skive HMM.ĭescription: Epigenetic selectivity of TopoIIα redistribution and histone eviction of anthracyclinesĪnthracyclines act by disrupting the interface of TopoII and DNA and by evicting histones. Capstone genes:SCN2A GABRA1 DLL1 ARID1B KMT2C SMARCC2 CHD8 CACNA1G ASX元 SHANK3ĭescription: Archaic fragments detected in GBR and CHS individuals from 1000 Genomes Project using Skive HMMĭescription: Archaic fragment enrichment in 20 individuals from GBR and CHS populations from 1kgp. It uses the multi-region tool to slice the genome over several chromosomes to display all the genes in one view. Capstone genes:ARID1B ASX元 CACNA1G CHD8 DLL1 GABRA1 KMT2C SCN2A SHANK3 SMARCC2ĭescription: This session is a view of the 10 capstone genes in the SSPsyGene project in order of chromosomes (a gene on chr2 before the gene on chr5). See the Sessions User's Guide for more information.ĭescription: This session is a view of the 10 capstone genes in the SSPsyGene project. You can add your own sessions to this list by checking the appropriate box on the Session Management page. The Public Sessions tool allows users to easily share those sessions that they deem interesting with the rest of the world's researchers. Sessions allow users to save snapshots of the Genome Browser and its current configuration, including displayed tracks, position, and custom track data.
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